Prof. Dr. Hermann Rohrer
Institute of Clinical Neuroanatomy
Theodor-Stern-Kai 7
D-60590 Frankfurt, Germany
Tel +49-176 72391448
E-Mail: rohrer@med.uni-frankfurt.de
Scientific Focus
The major topic of our research in recent years is the control of neurogenesis in sympathetic ganglia and adrenal medulla and aberrant development leading to neuroblastoma (NB). Our vision is that understanding normal sympathetic nervous system development will help us to find the important abnormal events that initiate NB development. Thus, we address the endogenous function of signaling pathways that are upregulated or mutated in NB and investigate effects of potential tumor drivers in cultures of sympathetic neuroblasts and in mouse NB models.
Methods
To identify and characterize molecules involved in normal sympathoadrenal development and NB initiation we use a combination of molecular, cellular and embryological approaches. In vivo transgenic approaches in mouse, retroviral expression in chick embryos and in vitro cultures of mouse and avian sympathetic neuroblasts are used for gain- and loss-of-function studies.
Selected Publications
Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma. Thirant C, Peltier A, Durand S, Kramdi A, Louis-Brennetot C, Pierre-Eugène C, Gautier M, Costa A, Grelier A, Zaïdi S, Gruel N, Jimenez I, Lapouble E, Pierron G, Sitbon D, Brisse HJ, Gauthier A, Fréneaux P, Grossetête S, Baudrin LG, Raynal V, Baulande S, Bellini A, Bhalshankar J, Carcaboso AM, Geoerger B, Rohrer H, Surdez D, Boeva V, Schleiermacher G, Delattre O, Janoueix-Lerosey I. Nat Commun. 2023 May 4;14(1):2575. doi: 10.1038/s41467-023-38239-5.
BET and CDK Inhibition Reveal Differences in the Proliferation Control of Sympathetic Ganglion Neuroblasts and Adrenal Chromaffin Cells. Sriha J, Louis-Brennetot C, Pierre-Eugène C, Baulande S, Raynal V, Kramdi A, Adameyko I, Ernsberger U, Deller T, Delattre O, Janoueix-Lerosey I, Rohrer H. Cancers (Basel). 2022 Jun 1;14(11):2755. doi: 10.3390/cancers14112755.
The sympathies of the body: functional organization and neuronal differentiation in the peripheral sympathetic nervous system. Ernsberger U, Deller T, Rohrer H. Cell Tissue Res. 2021 Dec;386(3):455-475. doi: 10.1007/s00441-021-03548-y. Epub 2021 Nov 10.
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries. Boeva V, Louis-Brennetot C, Peltier A, Durand S, Pierre-Eugène C, Raynal V, Etchevers HC, Thomas S, Lermine A, Daudigeos-Dubus E, Geoerger B, Orth MF, Grünewald TGP, Diaz E, Ducos B, Surdez D, Carcaboso AM, Medvedeva I, Deller T, Combaret V, Lapouble E, Pierron G, Grossetête-Lalami S, Baulande S, Schleiermacher G, Barillot E, Rohrer H, Delattre O, Janoueix-Lerosey I. Nat Genet. 2017 Sep;49(9):1408-1413. doi: 10.1038/ng.3921. Epub 2017 Jul 24.
Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.Kramer M, Ribeiro D, Arsenian-Henriksson M, Deller T, Rohrer H. J Neurosci. 2016 Oct 5;36(40):10425-10439. doi: 10.1523/JNEUROSCI.0183-16.2016.