PD Dr. Florian Freudenberg
Department of Psychiatry, Psychosomatics and Psychotherapy
Heinrich-Hoffmann-Str. 10
60528 Frankfurt am Main
Germany
+49 (0)69 6301-85665
E-Mail:florian.freudenberg@kgu.de
Scientific Focus
My group studies the molecular mechanisms involved in the pathophysiology of mental disorders applying cross-species and cross-disorder approaches. We utilize behavioural, molecular, and histological analyses of cell culture and mouse models, viral gene transfer, as well as the genetic and molecular investigation of human biosamples and omics data from human subjects. My group tightly collaborates with psychiatrists, pharmacologists, and psychologists to translate our findings to human patients. With this approach we aim to understand the complex nature of mental disorders and overcome the translational roadblock that hampered the development of new treatments for mental disorders for the last 50 years despite significant advances in the basic neurosciences.
Methods
Mouse behaviour, genetic mouse models, maternal immune activation, stress-based animal models, viral gene transfer, human and mouse primary cell cultures, qPCR, Western blotting, immunohistochemistry, morphological analyses, QTL mapping, genetic analyses
Selected Publications
Freudenberg F, Althen H, Falk K, Bittner RA, Reif A, Plichta MM (2022). Test-retest reliability of prepulse inhibition (PPI) and PPI correlation with working memory. Acta Neuropsychiatrica 34(6):344–353. https://doi.org/10.1017/neu.2022.19
Esen-Sehir D, Kopf J, Hägele S, Plichta MM, Reif A, Freudenberg F (2022). Influence of NOS1AP Risk Variants on the Corrected QT (QTc) Interval in the Pharmacotherapy of Schizophrenia. Pharmacopsychiatry 55(5):266–273. https://doi.org/10.1055/a-1811-7241
Freudenberg F, Candemir E, Chen X, Li L-L, Esen-Sehir D, Schenk N, Kinoshita M, Grünewald L, Frerichs V, Fattakhov N, Manchen J, Bikas S, Kumar A, OLeary A, Slattery DA, von Engelhardt J, Courtney MJ, Reif A (2021). Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders. EBioMedicine 71:103565. https://doi.org/10.1016/j.ebiom.2021.103565
Candemir E, Kollert L, Weißflog L, Geis M, Müller A, Post AM, O’Leary A, Harro J, Reif A, Freudenberg F (2016). Interaction of NOS1AP with the NOS-I PDZ domain: Implications for schizophrenia-related alterations in dendritic morphology. European Neuropsychopharmacology, 26(4):741–755. https://doi.org/10.1016/j.euroneuro.2016.01.008
Freudenberg F, Resnik E, Kolleker A, Celikel T, Sprengel R, Seeburg PH (2016). Hippocampal GluA1 expression in Gria1-/- mice only partially restores spatial memory performance deficits. Neurobiology of Learning and Memory 135:83–90. https://doi.org/10.1016/j.nlm.2016.07.005