Prof. Dr. David Slattery
Department of Psychiatry, Psychosomatics and Psychotherapy
Heinrich-Hoffmann-Str. 10
60528 Frankfurt am Main, Germany
Tel +49 69 6301 80012
E-Mail: d.slattery@med.uni-frankfurt.de
Scientific Focus
We are interested in understanding of the neurobiology and treatment of stress-related disorders; with an emphasis on mood and anxiety disorders. A particular focus is the study postpartum mood and anxiety disorders using stress- and diet-based models in rodents, as well as:
– The role of neuropeptides in anxiety- and affective- disorders
– The molecular basis of Social Anxiety Disorder and the assessment of novel treatment options
– Sex-differences in the aetiology and treatment of stress-related disorders
Methods
Behaviour
Stress-based animal models
Genetic mouse models
Neuroendocrinology
Selected Publications
Social anxiety disorder-associated gut microbiota increases social fear. Ritz NL, Brocka M, Butler MI, Cowan CSM, Barrera-Bugueño C, Turkington CJR, Draper LA, Bastiaanssen TFS, Turpin V, Morales L, Campos D, Gheorghe CE, Ratsika A, Sharma V, Golubeva AV, Aburto MR, Shkoporov AN, Moloney GM, Hill C, Clarke G, Slattery DA, Dinan TG, Cryan JF. Proc Natl Acad Sci U S A. 2024 Jan 2;121(1):e2308706120. doi: 10.1073/pnas.2308706120. Epub 2023 Dec 26.
Behavioural and functional evidence revealing the role of RBFOX1 variation in multiple psychiatric disorders and traits. O’Leary A, Fernàndez-Castillo N, Gan G, Yang Y, Yotova AY, Kranz TM, Grünewald L, Freudenberg F, Antón-Galindo E, Cabana-Domínguez J, Harneit A, Schweiger JI, Schwarz K, Ma R, Chen J, Schwarz E, Rietschel M, Tost H, Meyer-Lindenberg A, Pané-Farré CA, Kircher T, Hamm AO, Burguera D, Mota NR, Franke B, Schweiger S, Winter J, Heinz A, Erk S, Romanczuk-Seiferth N, Walter H, Ströhle A, Fehm L, Fydrich T, Lueken U, Weber H, Lang T, Gerlach AL, Nöthen MM, Alpers GW, Arolt V, Witt S, Richter J, Straube B, Cormand B, Slattery DA, Reif A. Mol Psychiatry. 2022 Nov;27(11):4464-4473. doi: 10.1038/s41380-022-01722-4
The future of rodent models in depression research. Gururajan A, Reif A, Cryan JF, Slattery DA. Nat Rev Neurosci. 2019 Nov;20(11):686-701. doi: 10.1038/s41583-019-0221-6
De Novo Protein Synthesis Mediated by the Eukaryotic Elongation Factor 2 Is Required for the Anxiolytic Effect of Oxytocin. Martinetz S, Meinung CP, Jurek B, von Schack D, van den Burg EH, Slattery DA, Neumann ID. Biol Psychiatry. 2019 May 15;85(10):802-811. doi: 10.1016/j.biopsych.2019.01.010
Selective breeding for high anxiety introduces a synonymous SNP that increases neuropeptide S receptor activity. Slattery DA, Naik RR, Grund T, Yen YC, Sartori SB, Füchsl A, Finger BC, Elfving B, Nordemann U, Guerrini R, Calo G, Wegener G, Mathé AA, Singewald N, Czibere L, Landgraf R, Neumann ID. J Neurosci. 2015 Mar 18;35(11):4599-613. doi: 10.1523/JNEUROSCI.4764-13.2015.