![Rosenow_2024_klein](https://www.izn-frankfurt.de/wp-content/uploads/2024/02/Rosenow_2024_klein-1.jpg)
Prof. Dr. med. Felix Rosenow, MHBA
Head, Epilepsy Center Frankfurt Rhine-Main
Department of Neurology, Neurocenter
Schleusenweg 2-16 (Haus 95)
60528 Frankfurt a.M.
Tel +49(0)69/6301-7466
Fax +49(0)69/6301-84466
E-Mail: rosenow@med.uni-frankfurt.de
Scientific Focus
Translational and clinical epilepsy research
Immune and vascular mechanisms of Epileptogenesis
Epilepsy genetics
Neurophysiology
Clinical trials
Methods
Experimental models of temporal lobe epilepsy
Neurophysiology including stereo-EEG
Genetic imaging, genetic neurophysiology
Selected Publications
Arlt FA, Miske R, Machule ML, Broegger Christensen P, Mindorf S, Teegen B, Borowski K, Buthut M, Rößling R, Sánchez-Sendín E, van Hoof S, Cordero-Gómez C, Bünger I, Radbruch H, Kraft A, Ayzenberg I, Klausewitz J, Hansen N, Timäus C, Körtvelyessy P, Postert T, Baur-Seack K, Rost C, Brunkhorst R, Doppler K, Haigis N, Hamann G, Kunze A, Stützer A, Maschke M, Melzer N, Rosenow F, Siebenbrodt K, Stenør C, Dichgans M, Georgakis MK, Fang R, Petzold GC, Görtler M, Zerr I, Wunderlich S, Mihaljevic I, Turko P, Schmidt Ettrup M, Buchholz E, Foverskov Rasmussen H, Nasouti M, Talucci I, Maric HM, Heinemann SH, Endres M; DEMDAS study group; Komorowski L, Prüss H. KCNA2 IgG autoimmunity in neuropsychiatric diseases. Brain Behav Immun. 2024 Feb 2;117:399-411. doi: 10.1016/j.bbi.2024.01.220. PMID: 38309639
International League Against Epilepsy Consortium on Complex Epilepsies. GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture. Nat Genet. 2023 Sep;55(9):1471-1482. doi: 10.1038/s41588-023-01485-w. PMID: 37653029
Heiland M, Connolly NMC, Mamad O, Nguyen NT, Kesavan JC, Langa E, Fanning K, Sanfeliu A, Yan Y, Su J, Venø MT, Costard LS, Neubert V, Engel T, Hill TDM, Freiman TM, Mahesh A, Tiwari VK, Rosenow F, Bauer S, Kjems J, Morris G, Henshall DC. MicroRNA-335-5p suppresses voltage-gated sodium channel expression and may be a target for seizure control. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2216658120. doi: 10.1073/pnas.2216658120. PMID: 37463203
Roberg LE, Monsson O, Kristensen SB, Dahl SM, Ulvin LB, Heuser K, Taubøll E, Strzelczyk A, Knake S, Bechert L, Rosenow F, Beier D, Beniczky S, Krøigård T, Beier CP. Prediction of Long-term Survival After Status Epilepticus Using the ACD Score. JAMA Neurol. 2022 Jun 1;79(6):604-613. doi: 10.1001/jamaneurol.2022.0609. PMID: 35404392
Strippel C, Herrera-Rivero M, Wendorff M, Tietz AK, Degenhardt F, Witten A, Schroeter C, Nelke C, Golombeck KS, Madlener M, Rüber T, Ernst L, Racz A, Baumgartner T, Widman G, Doppler K, Thaler F, Siebenbrodt K, Dik A, Kerin C, Räuber S, Gallus M, Kovac S, Grauer OM, Grimm A, Prüss H, Wickel J, Geis C, Lewerenz J, Goebels N, Ringelstein M, Menge T, Tackenberg B, Kellinghaus C, Bien CG, Kraft A, Zettl U, Ismail FS, Ayzenberg I, Urbanek C, Sühs KW, Tauber SC, Mues S, Körtvélyessy P, Markewitz R, Paliantonis A, Elger CE, Surges R, Sommer C, Kümpfel T, Gross CC, Lerche H, Wellmer J, Quesada CM, Then Bergh F, Wandinger KP, Becker AJ, Kunz WS, Meyer Zu Hörste G, Malter MP, Rosenow F, Wiendl H, Kuhlenbäumer G, Leypoldt F, Lieb W, Franke A, Meuth SG, Stoll M, Melzer N; German Network for Research on Autoimmune Encephalitis (GENERATE). A genome-wide association study in autoimmune neurological syndromes with anti-GAD65 autoantibodies. 2023 Mar 1;146(3):977-990. doi: 10.1093/brain/awac119. PMID: 35348614
Rosenow F, Winter Y, Leunikava I, Brunnert M, Joeres L, Sutphin J, Boeri M, Smith J, Villani F, Brandt C. Relative importance of clinical outcomes and safety risks of antiseizure medication monotherapy for patients and physicians: Discrete choice experiment eliciting preferences in real-world study “VOTE”. 2022 Feb;63(2):451-462. doi: 10.1111/epi.17137. PMID: 34921391
Kellinghaus C, Rossetti AO, Trinka E, Lang N, May TW, Unterberger I, Rüegg S, Sutter R, Strzelczyk A, Tilz C, Uzelac Z, Rosenow F. Factors predicting cessation of status epilepticus in clinical practice: Data from a prospective observational registry (SENSE). Ann Neurol. 2019 Mar;85(3):421-432. doi: 10.1002/ana.25416. PMID: 30661257