Prof. Dr. med. Jochen Roeper
Institut für Neurophysiologie
Theodor-Stern-Kai 7
60590 Frankfurt
Tel +49-(0)-69-6301-84091/2
Fax +49-(0)-69-6301-6987
E-Mail: roeper@em.uni-frankfurt.de
Scientific Focus
The group focusses on the physiology and pathophysiology of the dopaminergic midbrain system, which is involved in key brain functions like voluntary movement, motivation and cogition. The dopaminergic system is involved in major brain disorders like Parkinson diseases, Schizophrenia or ADHD. We study the mechanisms and chronic plasticity of ion channels and electrical activity generated by different subtypes of dopaminergic midbrain neurons and their role of function and dysfunction in the brain.
Methods
We mainly use in vitro and in vivo patch-clamp and microelectrode recordings in mouse brain combined with neuroanatomical tracing, stereology, immunohistochemistry and transgenic as well es neurotoxicological models.
Selected Publications
Optogenetic action potentials and intrinsic pacemaker interplay in retrogradely identified midbrain dopamine neurons.
Hammer N, Vogel P, Lee S, Roeper J.
Eur J Neurosci. 2023 Dec 6. doi: 10.1111/ejn.16208. Online ahead of print.
PMID: 38056070
Cav1.3 calcium channels are full-range linear amplifiers of firing frequencies in lateral DA SN neurons.
Shin J, Kovacheva L, Thomas D, Stojanovic S, Knowlton CJ, Mankel J, Boehm J, Farassat N, Paladini C, Striessnig J, Canavier CC, Geisslinger G, Roeper J.
Sci Adv. 2022 Jun 10;8(23):eabm4560. doi: 10.1126/sciadv.abm4560. Epub 2022 Jun 8.
PMID: 35675413 Free PMC article.
α-Synuclein-induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms.
Chiu WH, Kovacheva L, Musgrove RE, Arien-Zakay H, Koprich JB, Brotchie JM, Yaka R, Ben-Zvi D, Hanani M, Roeper J, Goldberg JA.
Sci Adv. 2021 Mar 10;7(11):eabd3994. doi: 10.1126/sciadv.abd3994. Print 2021 Mar.
PMID: 33692101 Free PMC article.
In vivo patch-clamp recordings reveal distinct subthreshold signatures and threshold dynamics of midbrain dopamine neurons.
Otomo K, Perkins J, Kulkarni A, Stojanovic S, Roeper J, Paladini CA.
Nat Commun. 2020 Dec 8;11(1):6286. doi: 10.1038/s41467-020-20041-2.
PMID: 33293613 Free PMC article.
In vivo functional diversity of midbrain dopamine neurons within identified axonal projections.
Farassat N, Costa KM, Stojanovic S, Albert S, Kovacheva L, Shin J, Egger R, Somayaji M, Duvarci S, Schneider G, Roeper J.
Elife. 2019 Oct 3;8:e48408. doi: 10.7554/eLife.48408.
PMID: 31580257 Free PMC article.