PD Dr. Stefan Momma
Goethe Universität Frankfurt
Neurologisches Institut (Edinger Institut)
Neuroscience Center, Raum 408
Heinrich-Hoffmann Strasse 7
60528 Frankfurt/Main
Tel: 069 6301 84158
Email: momma@em.uni-frankfurt.de
Scientific Focus
Cellular communication is fundamental to the organization and function of the organism, and extracellular vesicles (EVs) have recently emerged as a novel class of messengers enabling the transfer of complex molecular information between cells. Our research focuses on extracellular vesicles (EVs) as mediators of intercellular communication between the brain and periphery. We aim to understand how EV-mediated signaling shapes neural function under physiological conditions and in response to systemic and neurological challenges such as inflammation or neurodegenerative diseases. To address this, we use genetic tracing approaches (Cre–LoxP-based systems) to visualize and quantify the functional transfer of EV cargo in vivo.
Methods
- genetic mouse models;
- in vivo models for neurological diseases, tumors, inflammation;
- extracellular vesicles isolation, characterization, Cre-LoxP based tracing of EV signaling in vivo
Selected Publications
Peng H, Xin S, Pfeiffer S, Müller C, Merl-Pham J, Hauck SM, Harter PN, Spitzer D, Devraj K, Varynskyi B, Arzberger T, Momma S*, Schick JA* (2024). Fatty acid-binding protein 5 is a functional biomarker and indicator of ferroptosis in cerebral hypoxia. Cell Death Dis, 15(4), 286.
Bittel M, Reichert P, Sarfati I, Dressel A, Leikam S, Uderhardt S, Stolzer I, Phu TA, Ng M, Vu NK, Tenzer S, Distler U, Wirtz S, Rothammer V, Neurath MF, Raffai RL, Günther C, Momma S (2021). Visualizing transfer of microbial biomolecules by outer membrane vesicles in microbe-host-communication in vivo. J Extracell Vesicles, 10(12), e12159.
Kur IM, Prouvot PH, Fu T, Fan W, Müller-Braun F, Das A, Das S, Deller T, Roeper J, Stroh A, Momma S (2020). Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo. PLoS Biol, 18(3), e3000643.
Kraft A, Rosales Jubal E, von Laer R, Döring C, Rocha A, Grebbin M, Zenke M, Kettenmann H, Stroh A, Momma S (2017). Astrocytic calcium waves signal brain injury to neural stem and progenitor cells. Stem Cell Reports, 8(3), 701–714.
Ridder K, Keller S, Dams M, Rupp AK, Schlaudraff J, Del Turco D, Starmann J, Macas J, Depboylu C, Landfried B, Plate KH, Höglinger G, Sültmann H, Altevogt P, Momma S (2014). Exosomal transfer of genetic information between the hematopoietic system and the brain in response to inflammation. PLoS Biol, 12(6), e1001874.