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Prof. Jasmin Hefendehl

Campus Riedberg
Goethe Universität Frankfurt
Neurovascular Disorders
Institute of Cell Biology and Neuroscience
Buchmann Institute for molecular life sciences
Max-von-Laue-Straße 15
60438 Frankfurt am Main

Tel.: 49 (0)69-798-42528


Scientific Focus

Alzheimer’s Disease as well as vascular cognitive impairment are major health problems on our society. In fact, up to 80% of all dementia cases present themselves in a co-morbid manner with both AD and vascular cognitive impairment present in the patient. Hence, we are conducting basic research on the coocurrence of the two diseases to investigate underlying mechanisms and potential biomarkers. The neurovascular unit consist of multiple different cells that work in close coordination to regulates blood flow and blood brain barrier integrity and is of particular interest to us, as it is a common target in both diseases. We use a variety of methods to investigate disease related mechanisms on the genetic, functional and molecular level.


in vivo 2-Photon imaging, acute brain slice imaging, confocal microscopy, scRNA sequencing, primary cell culture, immunohistochemistry, molecular biology, protein biochemistry.

Selected Publications

Microglia Phenotypes Converge in Aging and Neurodegenerative Disease. M. Candlish and JK Hefendehl. Frontiers in Neurology May 2021

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. K. Degenhardt, J Wagner, A Skodras, M Candlish, AJ Koppelmann, K Wild, R Maxwell, C Rotermund, F von Zweydorf, CJ Gloeckner, HA Davies, J Madine, D Del Turco, R Feederle, T Lashley, TDeller, P Kahle, J K Hefendehl, M Jucker, and JJ Neher. PNAS Sep. 2020

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR Two- Photon imaging. JK. Hefendehl, J. LeDue, R. Ko, T. Murphy, B.A. MacVicar. Nature Comm Oct 2016

Comment on “ApoE-Directed Therapeutics Rapidly Clear b-Amyloid and Reverse Deficits in AD Mouse Models”. Veeraraghavalu K,* Zhang C,* Miller S,* Hefendehl JK,* Rajapaksha TW,* Ulrich J,* Jucker M, Holtzman DM, Tanzi RE , Vassar R, Sisodia SS. (shared first authorship). Science 2013 Jan 22 340, 924 (2013)

Long-term in vivo Imaging of β-Amyloid Plaque Appearance and Growth in a Mouse Model of Cerebral β-Amyloidosis. Hefendehl JK*, Wegenast-Braun BM*, Liebig C, Eicke D, Milford D, Calhoun ME, Eichner M, Jucker M.. J Neurosci. 2011 Jan 12;31(2):624-9.

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