Prof. Dr. Christine Ecker
Department of Child and Adolescent Psychiatry
Deutschordenstrasse 50
60528 Frankfurt am Main
+49 (0)69 6301 84705
E-Mail: christine.ecker@kgu.de
Scientific Focus
Our research efforts focus on the development of novel approaches to image analysis as applied to Magnetic Resonance Imaging (MRI) data with the aim of developing biomarkers that can be leveraged to (i) understand the neurobiology of complex neurodevelopmental conditions such as Autism Spectrum Disorders (ASD), and to (ii) provide targets for developing and monitoring pharmacotherapies and interventions.
Methods
Magnetic Resonance Imaging (MRI), image analysis, statistical learning
Selected Publications
Patterns of Cortical Folding Associated with Autistic Symptoms in Carriers and Noncarriers of the 22q11.2 Microdeletion. (2020). Patterns of Cortical Folding Associated with Autistic Symptoms in Carriers and Noncarriers of the 22q11.2 Microdeletion. http://doi.org/10.1093/cercor/bhaa108
Neuroanatomical underpinnings of autism symptomatology in carriers and non-carriers of the 22q11.2 microdeletion. (2020). Neuroanatomical underpinnings of autism symptomatology in carriers and non-carriers of the 22q11.2 microdeletion., 11(1), 46. http://doi.org/10.1186/s13229-020-00356-z
Bletsch, A., Mann, C., Andrews, D. S., Daly, E., Tan, G. M. Y., Murphy, D. G. M., & Ecker, C. (2018). Down syndrome is accompanied by significantly reduced cortical grey-white matter tissue contrast. Human Brain Mapping, 39(10), 4043–4054. http://doi.org/10.1002/hbm.24230
Mann, C., Bletsch, A., Andrews, D., Daly, E., Murphy, C., Murphy, D., & Ecker, C. (2018). The effect of age on vertex-based measures of the grey-white matter tissue contrast in autism spectrum disorder. Molecular Autism, 9(1), 49. http://doi.org/10.1186/s13229-018-0232-6
Gudbrandsen, M., Daly, E., Murphy, C. M., Wichers, R. H., Stoencheva, V., Perry, E., et al. (2018). The Neuroanatomy of Autism Spectrum Disorder Symptomatology in 22q11.2 Deletion Syndrome. Cerebral Cortex (New York, N.Y. : 1991), 31(3), 137. http://doi.org/10.1093/cercor/bhy239