Dr. Torfi Sigurdsson

Institute of Neurophysiology
Neuroscience Center
Theodor-Stern-Kai 7
60590 Frankfurt

Tel +69-6301-84098
Fax +69-6301-6987

sigurdssonem.uni-frankfurt.de

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Scientific Focus

Coordination of neural activity across brain regions is a fundamental principle of brain function. The main research focus of our group is to understand the mechanisms underlying neuronal coordination and how it underlies cognitive processes such as working memory. We are also interested in understanding how disruption of neural coordination contributes to the pathophysiology of psychiatric disorders such as schizophrenia.

A position for a Ph.D. student is currently available in the group. Interested applicants should send a single pdf file in English including a CV, a statement of research interest and the names and addresses of 3 references to Dr. Torfi Sigurdsson (sigurdsson@em.uni-frankfurt.de)

Methods

● Electrophysiological recordings in freely behaving animals
● Behavioral testing
● Animal models of psychiatric illness
● Analysis of neural activity and its coordination across brain regions
● Optogenetics

Selected Publications

Rummell BP, Klee JL, Sigurdsson T (2016) Attenuation of Responses to Self-Generated Sounds in Auditory Cortical Neurons. J Neurosci 36:12010–12026.

Sigurdsson T (2016) Neural circuit dysfunction in schizophrenia: Insights from animal models. Neuroscience 321:42–65.

Sigurdsson T, Duvarci S (2015) Hippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease. Front Syst Neurosci 9:190.

Sigurdsson T, Stark KL, Karayiorgou M, Gogos JA, Gordon JA (2010) Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia. Nature 464:763–767.

Sigurdsson T, Doyère V, Cain CK, LeDoux JE (2007) Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memory. Neuropharmacology 52:215–227.

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