Dr. Torfi Sigurdsson

Institute of Neurophysiology
Neuroscience Center
Theodor-Stern-Kai 7
60590 Frankfurt

Tel +69-6301-84098
Fax +69-6301-6987

sigurdssonem.uni-frankfurt.de

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Scientific Focus

Coordination of neural activity across brain regions is a fundamental principle of brain function. The main research focus of our group is to understand the mechanisms underlying neuronal coordination and how it underlies cognitive processes such as working memory. We are also interested in understanding how disruption of neural coordination contributes to the pathophysiology of psychiatric disorders such as schizophrenia.

A position for a Ph.D. student is currently available in the group. Interested applicants should send a single pdf file in English including a CV, a statement of research interest and the names and addresses of 3 references to Dr. Torfi Sigurdsson (sigurdsson@em.uni-frankfurt.de)

Methods

● Electrophysiological recordings in freely behaving animals
● Behavioral testing
● Animal models of psychiatric illness
● Analysis of neural activity and its coordination across brain regions
● Optogenetics

Selected Publications

Rummell BP, Klee JL and Sigurdsson T (in press). Attenuation of self-generated sounds in auditory cortical neurons. Journal of Neuroscience.

Sigurdsson T (2016) Neural circuit dysfunction in schizophrenia: Insights from animal models. Neuroscience 321:42–65.

Sigurdsson T, Duvarci S (2015) Hippocampal-Prefrontal Interactions in Cognition, Behavior and Psychiatric Disease. Front Syst Neurosci 9:190.

P-K O'Neill, J.A. Gordon and T. Sigurdsson (2013). Theta Oscillations in the Medial Prefrontal Cortex Are Modulated by Spatial Working Memory and Synchronize with the Hippocampus through Its Ventral Subregion. Journal of Neuroscience.

N.S. Burghardt, T. Sigurdsson, J.M. Gorman, B.S. McEwen and J.E. LeDoux. (2013). Chronic antidepressant treatment impairs the acquisition of fear extinction. Biological Psychiatry 73(11):1078-86.

A. Adikhari, T. Sigurdsson, M. Topiwala, and J.A. Gordon (2010). Cross-correlation of instantaneous amplitudes of field potential oscillations: a straightforward frequency-specific method to estimate the directionality and lag between brain areas. Journal of Neuroscience Methods 191(2): 191-200.

T. Sigurdsson, K.L. Stark, M. Karayiorgou, J.A.Gogos and J.A. Gordon (2010). Impaired Hippocampal-Prefrontal Synchrony in a Genetic Mouse Model of Schizophrenia. Nature 464: 763-7.

T. Sigurdsson, C.K. Cain, V. Doyere and J.E. LeDoux (2010). Asymmetries in long-term and short-term plasticity at thalamic and cortical inputs to the amygdala in vivo. European Journal of Neuroscience 31(2): 250:262.

T. Sigurdsson, V. Doyere, C.K. Cain and J.E. LeDoux (2007). Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memory. Neuropharmacology 52(1):215-227.

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