The research focus of the Computational Neuroscience Group at the Goethe-Center for Scientific Computing (G-CSC) is to understand basic neuronal functioning in the brain by applying advanced mathematical and computational methodology in the neuroscientific field. We develop computational methods, models and software for cellular and sub-cellular signal processing in nerve cells, e.g. signal processing in axons and calcium coding in the nucleus, based on theories from continuum mechanics.
We focus on detailed modeling of signal processing in neurons and small networks. We understand the word “detailed” as resolving three-dimensional morphology of the underlying neuronal organelle and modeling the underlying biophysics in a spatio-temporal fashion. In particular we are interested in signal processing on different scales and motivated to couple these with advanced mathematical and computational methods.
Queisser, G., Wittum, G. (2011) A method to investigate the diffusion properties of nuclear calcium. Biol. Cybern. 105(3-4):211-216
Queisser, G., Wiegert S., and Bading, H. (2011) Structural dynamics of the nucleus: Basis for Morphology Modulation of Nuclear Calcium Signaling and Gene Transcription. Nucleus. DOI: 10.4161/nucl.2.2.15116
Xylouris, K., Queisser, G., and Wittum, G. (2011) A Three-Dimensional Mathematical Model of Active Signal Processing in Axons. Comp. Vis. Sci. 13(8): 409-418
Jungblut, D., Queisser, G., Wittum, G. (in press) Inertia Based Filtering of High Resolution Images Using a GPU Cluster.
Wittmann, M., Queisser, G., Eder, A., Wiegert, J.S., Bengtson, C.P., Hellwig, A., Wittum, G., and Bading, H. (2009) Synaptic Activity Induces Dramatic Changes in the Geometry of the Cell Nucleus: Interplay Between Nuclear Structure, Histone H3 Phosphorylation, and Nuclear Calcium Signaling. The Journal of Neuroscience 29(47):14687-14700
Queisser, G., Wittmann, M., Bading, H., and Wittum, G. (2008) Filtering, reconstruction, and measurement of the geometry of nuclei from hippocampal neurons based on confocal microscopy data. Journal of Biomedical Optics 13, 014009.